Table 2.
Characterization for CDDP-responsive and non-responsive NP. Values reported as mean ± standard deviation of n = 5 independent NP preparations. ╪ for a 50 µmol lipid preparation—passive loading scaled with amount of lipid present.
| CDDP-NP (n = 5) |
Size, nm (PDI) |
Zeta Potential (mV) | % Loading Efficiency ╪ | Drug-to-Lipid Ratio (w/w) | Release Kinetics Fitting Parameters y = y∞ + exp(−t/τ 1/2 ) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| pH 7.4 | pH 6.5 | |||||||||
| pH 7.4 | pH 6.5 | pH 6.0 | y ∞ (%) | τ1/2 (min) | y ∞ (%) | τ1/2 (min) | ||||
| Responsive | 123 ± 5 (0.12 ± 0.05) |
−2.06 ± 0.41 | −0.97 ± 0.46 | −0.11± 0.47 | 5.8 ± 0.98 | 0.090 ± 0.011 | 87 ± 1.5 | 150 ± 45 | 71 ± 0.5 | 131 ± 7 |
| Non-Responsive | 115 ± 6 (0.10 ± 0.04) |
−4.57 ± 0.63 | −4.48 ± 0.56 | −4.15 ± 0.52 | 6.2 ± 0.73 | 0.103 ± 0.054 | 89 ± 0.3 | 133 ± 10 | 88 ± 0.3 | 157 ± 14 |