. 2021 Oct 18;22(20):11219. doi: 10.3390/ijms222011219

Table 2.

Effect of different compounds on the liver, kidney functions, and lipid profile.

Parameters	C	CSNPs	DBT	DBT–CSNPs	CCl₄	CCl₄-CSNPs	CCl₄-DBT	CCl₄-DBT–CSNPs	CCl₄-Cisplatin
ALT (U/L)	117.72 ± 2.54	118.3 ± 2.56	120.58 ± 3.74	122.5 ± 2.81	265.52 ± 4.33 *	258.31 ± 3.89 *^α	188.33 ± 2.74 *^#α	157.92 ± 6.09 *^#	215.8 ± 6.8 *^#α
AST (U/L)	146.19 ± 3.86	148.3 ± 3.69	152.78 ± 5.4	150.7 ± 4.7	302.1 ± 4.27 *	293.61 ± 3.89 *^α	224.1 ± 3.25 *^#α	187.49 ± 4.14 *^#	259.58 ± 6.07 *^#α
ALP (U/L)	252.85 ± 2.08	254.25 ± 2.09	257.8 ± 4.1	255.85± 4.29	456.31 ± 5.58 *	446.49 ± 5.41 *^α	352.16 ± 4.05 *^#α	314.9 ± 3.44 *^#	375.2 ± 5.72 *^#α
TP (g/dl)	5.89 ± 0.042	5.87 ± 0.037	5.80 ± 0.035	5.84 ± 0.037	4.99 ± 0.033 *	5.06 ± 0.039 *^α	5.57 ± 0.045 *^#	5.67 ± 0.035 *^#	5.08 ± 0.095 *^α
Liver TP (mg/g tissue)	143.1 ± 7.38	143.6 ± 3.92	139.8 ± 4.34	141.2 ± 3.77	91.03 ± 5.88 *	87.21 ± 5.22 *^α	105.2 ± 7.15 *^#	121.1 ± 5.23 *^#	83.5 ± 4.75 ^*α
Albumin (g/dL)	4.99 ± 0.33	4.91 ± 0.28	4.88 ± 0.063	4.84 ± 0.057	3.48 ± 0.15 *	3.57 ± 0.14 *^α	3.91 ± 0.025 *^#	3.77 ± 0.057 *^#	3.35 ± 0.054 *^α
Cholesterol (mg/dL)	88.75 ± 2.39	90.3± 2.31	91.17± 3.98 *	93.08 ± 2.16	165.44 ± 2.32 *	160.7 ± 4.21 *^α	131.11 ± 2.61 *^#	128.94 ± 2.57 *^#	153.78 ± 2.39 *^#α
TG (mg/dL)	87.49 ± 1.58	89.2 ± 1.62	90.08 ± 2.16	92.07 ± 2.8	148.03 ± 2.27 *	145.9 ± 3.26 *^α	128.75 ± 1.67 *^#α	123.84 ± 2.78 *^#	133.3 ± 1.9 *^#α
LDL–cholesterol (mg/dL)	55.61 ± 1.5	56.69 ± 1.54	61.19 ± 1.96	58.69 ± 1.56	93.1± 1.87 *	90.2 ± 2.83 *^α	78.28 ± 2.2 *^#α	70.79 ± 1.45 *^#	86.59 ± 2.01 *^#α
HDL–cholesterol (mg/dL)	47.61 ± 1.45	45.2 ± 1.42	44.37 ± 1.51	42.88 ± 1.86	27.95 ± 2.09 *	28.9 ± 1.93 *^α	40.22 ± 1.17 *^#	41.42 ± 0.87 *^#	33.74 ± 1.74 *^#α
Urea (mg/dL)	43.79 ± 2.16	45.2 ± 2.19	46.74 ± 2.35 *	45.07 ± 3.96	73.21 ± 2.98 *	71.6 ± 1.09 *^α	65.76 ± 3.19 *^#α	58.74 ± 2.35 *^#	69.74 ± 2.26 *^α
Creatinine (mg/dL)	0.95 ± 0.02	0.97 ± 0.13	0.99 ± 0.108	1.03 ± 0.04	1.5 ± 0.068 *	1.42 ± 0.071 *^α	1.38 ± 0.049 *^#α	1.21 ± 0.027 *^#	1.44 ± 0.04 *^α

Values represent the mean ± SD of eight rats. One-way ANOVA followed by Tukey’s test was used (* p < 0.05 versus saline control group, # p < 0.05 versus CCl₄ group & α p < 0.05 versus DBT–CSNP-treated group).