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Rationale for melanoma polychemotherapy loaded in nanoemulsions. Abbreviations: Akt: protein kinase B; BVZ: bevacizumab; ERK: extracellular signal-regulated kinases; FOXO: forkhead box O; Mcl-1: Induced myeloid leukemia cell differentiation protein 1; mTOR: mammalian target of rapamycin; PTEN: phosphatase and tensin homolog; RAP: rapamycin; ROS: reactive oxygen species; SOD: superoxide dismutase; TMZ: temozolomide; VEGF: vascular endothelial growth factor.
