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. 2021 Sep 24;13(10):1549. doi: 10.3390/pharmaceutics13101549

Figure 5.

Figure 5

Cytotoxic effect of AuNPs per se and their complexes with target siRNA (siMCL-1 or siBCL-xL and RNA with a random sequence (rndRNA) on (a) HeLa, (b) HL-60, and (c) CEM-SS cells after 72 h incubation. AuNP concentrations correspond to optimal delivery concentrations based on previous calculations (100 µg/mL for AuNP13; 25 µg/mL for AuNP14; 10 µg/mL for AuNP15). Data obtained from MTT assay normalized to untreated cells (NT). Statistical significance between AuNP per se and AuNP-rndRNA (* p < 0.01); AuNP-rndRNA and AuNP-siRNA (** p < 0.005) was estimated by the post-hoc.