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. 2021 Oct 9;13(10):1646. doi: 10.3390/pharmaceutics13101646

Table A4.

List of aptamers for various other viruses which have not been discussed in this review.

Reference Virus Virus Type Detection/Therapy Mode of Therapy/Detection Detection Limit/Binding Affinity Target RNA/DNA Size
[167] Apple stem pitting virus Detection Molecularly Imprinted Polymer Gel Laser Diffraction Sensor 10 ng/mL MT32 protein DNA 40 nt
[168] bovine viral diarrhea virus BVDV type 1 Detection Gold nano sandwich sensor 800 copies/mL Whole Virus DNA 30 nt
[169] Coronavirus SARS Detection Aptamer on Chip 0.1 pg/mL nucleocapsid protein RNA 92 nt
[170] Norovirus Human noroviruse Detection ELASA NoV target-the P domain protein DNA
[171] Norovirus GII.2 HuNoV strain, Snow Mountain Virus Detection Kd 191 nM Immobilized SMV DNA 40 nt
[172] Norovirus Murine Norovirus Detection Kd 290 nM G-quadruplexes 20 aM to 120 aM Viral SELEX DNA 40 nt
[173] Porcine reproductive and respiratory syndrome virus VR-2332 Detection Kd 2.5 × 105 TCID50/mL In water 0.1 × 100–101 TCID50/mL Nasal/oral fluid 4.8 × 100–5.0 × 103 TCID50/mL Viral SELEX DNA 40 nt
[174] Vaccinia virus Detection Kd 26.3–40.9 nM In water 60 PFU in 30 μL in blood 150 to 900 PFU Viral SELEX DNA
[175] vaccinia virus Detection Impedimetric 60 virions in a microliter Virus Infected Cell SELEX DNA 40 nt
[176] vesicular stomatitis virus Oncolytic Virus Detection To protect the Virus from Nuetralizing antibodies 53–86% degree of Protection Viral SELEX DNA 40 nt
[177] VSV vesicular stomatitis virus Detection aptamer-based affinity chromatography switchable aptamers
[178] Apple stem pitting virus isolates Detection ELONA 81% affinity MT32/PSA-H protein DNA 20-80 nt
[179] Bovine Herpes Virus-1 Detection/Therapy SELEX 3.5 nM gD protein DNA 38-51 nt
[180] Dengue Virus Detection SELEX 5’-UTR RNA
[181] Human Papilloma virus (HPV) Detection SELEX 10 nM type 16 VLP DNA
[182] Iridovirus Detection ELISA nmol L−1 DNA 71 nt
[183] Parvovirus Detection SELEX 467 nM DNA 49 nt
[184] Respiratory Syncytial Virus (RSV) Detection SELEX 0.5 nM F protein DNA 30 nt
[185] Sindbis virus Detection ISH/RT-PCR High affinity E2 glycoprotein RNA
[186] Alphavirus TC-83 Virus Therapy Replicon riobozyme actuator Vaccine RNA
[187] Coronavirus SARS Therapy Just binding studies Kd 4–9 nM nucleocapsid protein DNA 45 nt
[188] Dengue Therapy DENV-2 envelop protein domain III (ED3) DNA 15 nt
[189] Dengue DENV-2 Therapy Thiolated aptamers Kd 154 nM envelope protein domain III DNA 24 nt
[190] Ebola VP35 Therapy Inhibition of VP35 10–50 nM Viral Protein 35 RNA 45 nt
[191] foot-and-mouth disease virus Therapy GFP tagged aptamers 375 nM RNA-dependent RNA polymerase RNA 30 nt
[192] Hemorrhagic Septicemia Virus Therapy Viral plaques were reduced by 50%, cells were viable and healthy Viral SELEX RNA 40 nt
[193] Hirame Rhabdovirus Therapy 15- to 63-fold reduction in plaques Viral SELEX RNA 40 nt
[194] HPV HPV-16 Therapy Binding Inhibition HPV-16 E7 protein RNA
[195] HPV HPV-16 Therapy Kd = 0.05 pM HPV-16 L1 VLPs RNA 15 nt
[196] HPV HPV-16 Therapy Internalization of aptamers 5 fold higher internalization HPV-16 E6/E7 transformed tonsillar epithelial cell SELEX RNA 30 nt
[197] Iridovirus Singapore grouper Therapy inhibition 12.09 nM SGIV-infected GS cells DNA
[198] Iridovirus Singapore grouper Therapy 30% less mortality of fish Whole Virus DNA 50 nt
[199] Norovirus Therapy capsid protein VP1 DNA 49 nt
[200] rabies Therapy 25–33% survival Kd 307 nM RABV glycoprotein DNA 45 nt
[201] rabies Therapy 30–50% survival Cell SELEX DNA
[202] rabies Therapy 4 nmol PEG-FO24 protected 87.5% RABV-infected BHK-21 DNA 45 nt
[203] rabies Therapy Kd 28–39 nM Virus infected Cell SELEX DNA 45 nt
[204] Rift Valley fever virus Therapy nucleocapsid protein RNA 30 nt
[205] xenotropic murine leukemia virus-related virus (XMRV) Different from HIV-1 Therapy IC50 2 nM XMRV RT RNA three 12 nt sequences