Figure 6.

Time–activity curves of free actinium-225 (²²⁵Ac) after Ca-DTPA and Ca-TTHA administration in major organs, urine, and feces. Time–activity curves were generated using the biodistribution of ²²⁵Ac in control mice and mice with Ca-DTPA and Ca-TTHA at 4 and 24 h after ²²⁵Ac injection. Values are shown as mean ± SD; n = 4–5. Numbers in the graphs show the % increase (positive) or decrease (negative) of the area-under-the-curve in each chelator group, compared to the control. § indicates the statistical significance of time–activity curves (p < 0.05, vs. control). NS = not significant. * indicates statistical significance at each time point (p < 0.05, vs. control). The data for the other organs are shown in Figure S2.