Table 2.
Univariable analysis of predictors for anti-s IgG seroconversion.
| Responders n = 73 | Nonresponders n = 69 | p-Value | |
|---|---|---|---|
| Age years median (IQR) | 48.0 (40–61) | 58.0 (50–66) | 0.002 |
| Sex male n (%) | 44 (60.3) | 39 (56.5) | 0.65 |
| BMI kg/m2 median (IQR) | 25.01 (23.11–28.37) | 25.35 (22.49–28.41) | 0.33 |
| CCI median (IQR) | 3 (2–5) | 4 (3–6) | 0.079 |
| Diabetes n (%) | 16 (21.92) | 20 (28.98) | 0.33 |
| Transplant vintage years median (IQR) | 10.0 (6–19) | 7.0 (2.5–12) | 0.002 |
| Deceased donor n (%) | 69 (94.52) | 64 (92.75) | 0.67 |
| Serum creatinine mg/dl median (IQR) | 1.31 (1.03–1.58) | 1.39 (1.14–1.77) | 0.13 |
| Induction in history n (%) | 16 (21.9) | 23 (33.3) | 0.13 |
| >2 drugs immunosuppression n (%) | 46 (65.83) | 57 (82.61) | 0.009 |
| Corticosteroids n (%) | 65 (89.04) | 65 (94.2) | 0.27 |
| MMF/MPS n (%) | 52 (71.2) | 60 (86.9) | 0.02 |
| mRNA-1273 vaccine n (%) | 23 (31.5) | 14 (20.3) | 0.13 |
Legend: CCI; Charlson comorbidity index; BMI, body mass index; MMF/MPS, mycophenolate mofetil/Na. The use of more than two immunosuppressive agents (p = 0.01), shorter transplantation vintage (p = 0.003), and older age (p < 0.001) maintained statistical significance in the multivariable analysis (Table 3). This regression analysis was statistically significant (χ2 = 29.95, p < 0.001). The Hosmer–Lemeshow test revealed a good fit (χ2 = 7.09), and the Nagelkerke R2 effect size (R2 = 0.25) demonstrated good predictive efficacy.