Figure 1.

Sequencing results. Black bars represent positions with nucleotides that differ from the reference sequence MN908947. Red bars represent positions with minority nucleotide variants that differ from the reference sequence MN908947. White space represents regions whose coverage is lower than 10×. Nucleotide (normal font) and amino acid (bold font) changes are indicated at the top of the figure. Although the genome coverage obtained for sample 1b was too low to be reported in the figure, thus making the temporal variability analysis for this patient unfeasible, sample 1a is reported to show the presence of the nucleotide mutations at positions 241 and 3037 as well as D614G and P4715L in all samples. NPS = nasopharyngeal swab, NPA = nasopharyngeal aspiration, BAL = bronchoalveolar lavage, S = spike, E = envelope, M = matrix, N = nucleocapsid genes.