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. 2021 Sep 28;10(10):1250. doi: 10.3390/pathogens10101250

Figure 2.

Figure 2

Evaluation of the natural immunogenicity of predicted C. burnetii epitopes: (a) Reactivity indices against predicted epitopes of patients reactive (gray points) and non-reactive (white points) to C. burnetii in IFA. (b) Frequencies of response against predicted epitopes. (c) The magnitude of IgG response against synthetic peptides. The reactivity indices (RI) represent the ratios between the optical density of each reaction to C. burnetii and the cutoff value, defined as the mean of the control group’s optical densities plus twice their standard deviation. Each point represents an individual R.I. against one of the synthetic peptides (OMP-H(51–59), OMP-H(91–106), Com-1(57–76), Com-1(191–206), OMP-P1(197–209),, or OMP-P1(215–227)), the traced line indicates the cutoff, while lines represent the median and interquartile range (SEM) of reactive (gray points) and non-reactive (white points) patients to the studied peptides. The comparison of frequencies was done using Fisher´s exact test, and statistical differences were represented by p-values among bars. The magnitudes of response against predicted epitopes are indicated by gray boxes and whiskers (10th–90th percentile), with outliers –indicated by black points in the last graph.