Figure 4.

Compound-mediated changes in pAkt/Akt in DU145 cells. DU145 cells were treated with SAHA, Jazz90 and Jazz167 at 1 and 4 µM. Vehicle control cells (C) were treated with 0.5% DMSO. Cells were harvested 24 h after treatment. Representative Western blots of (a) pAkt, Akt and β-actin (loading control) and their (b) densitometry are shown. Bars represent the mean ± S.E.M. from 3 independent experiments. Data were analysed using a two-way ANOVA followed by a Bonferroni’s post-hoc test. None were significantly different.