Figure 8.

TnI, creatinine and ALT activity in BALB/c mice following compound treatment. Jazz90 and Jazz167 were orally administered at 25, 50 and 75 mg/kg in BALB/c mice daily for 21 days. On day 22, the mice were necropsied, and blood was collected from the inferior vena cava. Plasma (a) TnI, (b) creatinine and (c) ALT activity were measured. Columns indicate the mean ± S.E.M and points represent individual results from each mouse. Data were analysed using a two-way ANOVA coupled with a Bonferroni’s post-hoc test. None were significantly different.