Figure 1.

Overall trend in metabolome profiles. (a) Timeline of urine collection from inpatients. (b) Log2-ratio of the metabolome profile of AKI vs. non-AKI, represented by the color gradient from blue to yellow in the heat map. The metabolome profiles of the 2nd group (right) were listed in order based on the results of metabolome profile clustering in the 1st group (left). Dark gray represents an insufficient number of subjects. The cluster of metabolites showing downregulation in patients with AKI are marked in red. We did not have a sufficient number of samples at 48 h in the 2nd group, and they were omitted from the heatmap. The heatmap was generated using the heatmap.2 function in the gplots package of R, and layout and appearances were edited with Adobe Illustrator.