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. 2021 Oct 12;22(20):10997. doi: 10.3390/ijms222010997

Figure 5.

Figure 5

Menthol increases intracellular Ca2+ in cells transfected with dTRPA1 isoforms. (ad) Example traces of changes of intracellular Ca2+ concentration induced by menthol (0.3–1 mM) and AITC (100 µM) in HEK293T cells expressing: dTRPA1(A), dTRPA1(B), dTRPA1(C) or dTRPA1(D). (e,f) Concentration dependence of the average amplitude of intracellular Ca2+ increase induced by menthol; panel (e) raw data and panel (f) data obtained by normalizing to the amplitude of the response to AITC in each cell. n = 127, 210, 43 and 65 for isoforms A to D, respectively.