Table 1.
Veterinary products with macrocyclic lactones, registered in the USA or Europe for heartworm prevention in dogs and cats *.
| Active Molecule ** | Target Species | Application Route/Administration | Product/Company | Combination Molecule(s) |
|---|---|---|---|---|
| Eprinomectin | cat | topical/monthly | Centragard 2/Boehringer lngelheim | Praziquantel |
| NexGard Combo 3/Boehringer lngelheim | Esafoxolaner, Praziquantel |
|||
| Broadline 3/Boehringer lngelheim | Fipronil, Praziquantel, (S)-Methoprene |
|||
| Ivermectin | dog, cat | oral/monthly | Heartgard 2/Boehringer lngelheim Iverhart 2/Virbac Ivermectin 2/Cronus Pharma |
- |
| dog | topical/monthly | Advantage DUO 2/Elanco | Imidacloprid | |
| oral/monthly | Heartgard Plus 2/Boehringer lngelheim Iverhart Plus 2/Virbac Tri-Heart Plus 2/Heska |
Pyrantel | ||
| Panacur Plus 2/Intervet | Praziquantel, Fenbendazole |
|||
| Iverhart Max 2/Virbac | Praziquantel, Pyrantel |
|||
| Heartgard Plus 3/Boehringer lngelheim | Pyrantel | |||
| Cardotek Plus 3/Boehringer lngelheim | ||||
| Cardotek 3/Boehringer lngelheim | - | |||
| Milbemycin oxime | dog, cat | oral/monthly | Interceptor 1/Elanco MilbeGuard 2/Ceva Sante Animale |
- |
| Interceptor Plus 1/Elanco Milbemax 3/Elanco Milbactor 3/Ceva Sante Animal Milprazon 3/Krka Milquantel 3/Krka Milpro 3/Virbac |
Praziquantel | |||
| dog | oral/monthly | Sentinel 2/Intervet Program plus 3/Elanco |
Lufenuron | |
| Sentinel Spectrum 2/Intervet | Lufenuron, Praziquantel |
|||
| Interceptor Plus 2/Elanco | Praziquantel | |||
| Trifexis 1/Elanco | Spinosad | |||
| NexGard Spectra 3/Boehringer lngelheim | Afoxolaner | |||
| Credelio Plus 3/Elanco | Lotilaner | |||
| Moxidectin | dog, cat | topical/monthly | Prinovox 3/Virbac | Imidacloprid |
| Advantage Multi 2/Elanco | ||||
| Imoxi 2/Vetoquinol | ||||
| Advocate 3/Elanco | ||||
| dog | oral/monthly | Simparica Trio 1/Zoetis | Sarolaner, Pyrantel | |
| ProHeart 2,4/Zoetis | - | |||
| inj./6 month | Proheart 6 2/Zoetis | |||
| Guardian 3***/Elanco | ||||
| Afilaria 3/Fatro, Support Pharma | ||||
| inj./12 month | Proheart 12 2/Zoetis | |||
| topical/monthly | Coraxis 2/Elanco | |||
| cat | topical/monthly | Bravecto Plus 1/Intervet | Fluralaner | |
| Selamectin | dog, cat | topical/monthly | Revolution 2/Zoetis | - |
| Revolt 2/Aurora Selarid 2/Norbrook Lab. Senergy 2/Chanelle Stronghold 3/Zoetis Chanhold 3/Chanelle Evicto 3/Virbac Stronghold Plus 3/Zoetis |
Sarolaner | |||
| cat | topical/monthly | Revolution Plus 2/Zoetis Stronghold Plus 3/Zoetis Felisecto Plus 3/Zoetis |
* Information retrieved from the European Medicines Agency (https://www.ema.europa.eu/en, accessed the 5th of August 2021), the U.S. Food and Drug Administration (https://animaldrugsatfda.fda.gov/adafda/views/#/search accessed the 5th of August 2021), and from [5] for Europe and the USA. ** For heartworm prevention. *** To be administered yearly, the first month of mosquito activity, according to the drug instructions in Europe. 1 registered in USA and Europe. 2 registered in USA only. 3 registered in Europe only. 4 registered in the USA, but no longer available