Table 5.

Pharmacokinetic properties of the compounds predicted by in silico method.

Compound	GI Absorption	BBB Permeant	P-gp Substrate	CYP1A2 Inhibitor	CYP2C19 Inhibitor	CYP2C9 Inhibitor	CYP2D6 Inhibitor	CYP3A4 Inhibitor	Log Kp (Skin Permeation)
AT	High	No	No	Yes	No	No	Yes	No	−6.18 cm/s
HAT	High	No	No	Yes	No	No	No	No	−5.82 cm/s
MED	High	Yes	No	No	No	No	No	No	−6.67 cm/s

GI: gastrointestinal; BBB: blood–brain barrier; P-gp: P-glycoprotein; CYP: cytochrome P450.