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. 2021 Oct 4;13(10):1992. doi: 10.3390/v13101992

Figure 1.

Figure 1

Overview of miRNA biogenesis. Biogenesis consists of the miRNA gene transcription and maturation that involves the following steps: Pri-miRNA processing by DROSHA; Processing of pre-miRNA by DICER; Other modifications to produce mature miRNA and RISC complex formation to further mature miRNAs regulate mRNA and consequently interfere in protein production. Figure created by authors using BioRender.com.