Figure 1.

Orange boxes indicate pathophysiological triggers of tissue damage. Light cyan boxes describe metabolic pathways, in which metabolites from the dataset are involved. These metabolic pathways are involved in MS pathophysiology through alteration of biological functions such as small molecule biochemistry, controls of cell death, metabolic disease and cell to cell signalling. Dark orange boxes represent the endpoint of the metabolic cascades that lead to tissue damage and death. Upstream regulators, i.e., molecular regulator of metabolite expression, as identified by our pathway analysis, can promote tissue damage and death directly or through an activation of the immune system. These regulators and their effects are indicated in green (for huntingtin, an endogenous product) and in yellow (for curcumin, an exogenous product).