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. 2021 Oct 11;14(10):1030. doi: 10.3390/ph14101030

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of intracerebroventricular IL-1ß-saporin conjugate administration on brain perivascular cells in the organum vasculosum laminae terminalis (OVLT; A,C,D) and amygdala (B,E,F). In these structures, the IL-1ß-saporin conjugate reduced the number of CD163 immunoreactive (CD163 i.r.) cells (A–F) without affecting labelling for the endothelial cell marker von Willebrand factor (C,D) and the astrocyte marker glial fibrillary acidic protein (E,F). Brown labeling indicates von Willebrand factor (C,D) and glial fibrillary acidic protein (E,F) and black staining CD163. * p < 0.05; *** p < 0.001. IL1-SAP compared to IL1 + SAP group. IL1: interleukin-1ß; IL1-SAP: interleukin-1ß conjugated to saporin; IL1 + SAP: interleukin-1ß not conjugated to saporin; PBS: phosphate-buffered saline; SAP: saporin. Group sizes: n = 5–9. Scale bar represents 100 µm.