TABLE 1.
MIC, mutation position, and amino acid alteration in the β subunit and base alteration in the rpoB gene resulting in rifampin resistance in L. monocytogenes
| Mutant no. | Rifampin MIC (μg/ml) | Amino acid
|
Base change | Rifr clustera | |
|---|---|---|---|---|---|
| Position | Change | ||||
| 7 | 15 | 473 | Asp→Asn | GAT→AAT | I |
| 8 | 5 | 473 | Asp→Asn | GAT→AAT | I |
| 5 | 0.5 | 473 | Asp→Gly | GAT→GGT | I |
| 20 | 100 | 479 | Gly→Asp | GGC→GAC | I |
| 22 | 100 | 483 | His→Tyr | CAT→TAT | I |
| 23 | 10 | 483 | His→Leu | CAT→CTT | I |
| 14 | 5 | 528 | Ile→Phe | ATT→TTT | II |
| 6, 17 | 0.5 | 530 | Ser→Tyr | TCC→TAC | II |
Homologous position of mutation in relation to E. coli Rifr clusters.