Table 2.
Specificity of proline-specific peptidases.
| Number | Peptidase Class | Enzymes | Substrates 1 |
|---|---|---|---|
| 1 | Serine peptidases | Prolyloligopeptidase (POP), prolylendopeptidase (РЕР), fibroblast activation protein (FAP) |
(Xaa)n-Xbb-Pro↓Xbb-(Xaa)n, n = 1–13 (the length of the peptide is approximately 30 amino acid residues) |
| 2 | Dipeptidylpeptidases (DPP) 2, DPP 4, DPP 8, DPP 9, FAP |
Xbb-Pro↓Xbb-(Xaa)n, n = 2–12 | |
| 3 | Prolylcarboxypeptidase (PRCP) | (Xaa)n-Xbb-Pro↓Xbb, n—any number | |
| 4 | Metallopeptidases | Aminopeptidases P (APP) 1, APP2, APP3 |
Xbb↓Pro(Xaa)n, n = 1–9 |
| 5 | Prolidase | Xbb↓Pro |
1 Xaa—any amino acid; Xbb—any amino acid, except Pro.