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. 2021 Oct 14;22(20):11057. doi: 10.3390/ijms222011057

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Treatment of tumor-bearing mice with cetuximab and Pam3CSK4 results in prolonged survival. Nude mice (six/group) were subcutaneously injected with ADCC-insensitive UM-SCC-47 cells in both flanks. When tumors reached a tumor volume of approximately 70 mm³, intraperitoneal treatments were started (day 0). Mice were treated with (A) PBS (vehicle), (B) Pam3CSK4 (50 µg/mouse), (C) cetuximab (CTX, 1 mg/mouse) or (D) cetuximab with Pam3CSK4. Treatment days are indicated with arrows (day 0, 3, 7, 10, 17 and 24). Tumor volume is depicted as the mean of two tumors (both flanks, mm³) per mouse. Fragmented grey line represents a tumor volume of 100 mm³. (E) Relative survival rate of mice in the different treatment groups (six mice/group set at 100%).