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. 2021 Sep 23;9(10):1062. doi: 10.3390/vaccines9101062

Table 1.

Parameters for estimation of cost and effectiveness in the decision tree model.

Parameters Baseline Value Minimum Value Maximum Value Source of Data
Cost
Government procurement price of vaccines (CNY/vial)
tOPV (for 10-dose) 9.70 9.70 9.70 China Government Procurement Network
bOPV (for 10-dose) 27.20 27.20 27.20 China Government Procurement Network
sIPV (for 1-dose) 35.00 35.00 35.00 China Government Procurement Network
wIPV (for 1-dose) 39.00 39.00 39.00 China Government Procurement Network
Coefficient of loss
10-dose per vial 1.80 1.80 2.50 Practical Regulations for Vaccination in Shanghai (2017 edition) [33]; SCDC
1-dose per vial 1.00 1.00 1.05 Practical Regulations for Vaccination in Shanghai (2017 edition) [33]; SCDC
Procurement ratio of sIPV:wIPV 2:1 1:1 2:1 SCDC
Procurement price of the low-temperature refrigerator (CNY) 15,000 10,000 20,000 SCDC
Depreciation of low-temperature refrigerator (years) 9 8 10 SCDC
Compensation for VAPP cases (CNY, per case) 748,005 748,005 1,250,000 SCDC; Shanghai Compensation Measures for Vaccination Related Adverse Events (trial edition) [35]; Yang LS [21]
Effectiveness
Number of local resident births in Shanghai in 2016 (per 10,000) 21.84 21.84 21.84 Shanghai Statistical Yearbook 2017 [29]
Incidence of VAPP (per 1 million births)
Four-tOPV schedule 6.20 0.41 43.70 SCDC; WHO study [39]
Two-IPV-two-bOPV schedule 0.70 0.00 1.56 SCDC; WHO position paper [1]; Sutter et al. [40]; Ivanova et al. [41]
Four-IPV schedule 0 0 0
DALY caused by VAPP 14 13 14 Duintjer et al. [12], and Thompson et al. [14]

bOPV, bivalent live attenuated oral polio vaccine; tOPV, trivalent live attenuated oral polio vaccine; CNY, Chinese Yuan; DALY, disability-adjusted life year; ICER, incremental cost-effectiveness ratio; IPV, inactivated polio vaccine; SCDC, Shanghai Municipal Center for Disease Control and Prevention; VAPP, vaccine-associated paralytic poliomyelitis.