Table 1.
Parameters | Baseline Value | Minimum Value | Maximum Value | Source of Data |
---|---|---|---|---|
Cost | ||||
Government procurement price of vaccines (CNY/vial) | ||||
tOPV (for 10-dose) | 9.70 | 9.70 | 9.70 | China Government Procurement Network |
bOPV (for 10-dose) | 27.20 | 27.20 | 27.20 | China Government Procurement Network |
sIPV (for 1-dose) | 35.00 | 35.00 | 35.00 | China Government Procurement Network |
wIPV (for 1-dose) | 39.00 | 39.00 | 39.00 | China Government Procurement Network |
Coefficient of loss | ||||
10-dose per vial | 1.80 | 1.80 | 2.50 | Practical Regulations for Vaccination in Shanghai (2017 edition) [33]; SCDC |
1-dose per vial | 1.00 | 1.00 | 1.05 | Practical Regulations for Vaccination in Shanghai (2017 edition) [33]; SCDC |
Procurement ratio of sIPV:wIPV | 2:1 | 1:1 | 2:1 | SCDC |
Procurement price of the low-temperature refrigerator (CNY) | 15,000 | 10,000 | 20,000 | SCDC |
Depreciation of low-temperature refrigerator (years) | 9 | 8 | 10 | SCDC |
Compensation for VAPP cases (CNY, per case) | 748,005 | 748,005 | 1,250,000 | SCDC; Shanghai Compensation Measures for Vaccination Related Adverse Events (trial edition) [35]; Yang LS [21] |
Effectiveness | ||||
Number of local resident births in Shanghai in 2016 (per 10,000) | 21.84 | 21.84 | 21.84 | Shanghai Statistical Yearbook 2017 [29] |
Incidence of VAPP (per 1 million births) | ||||
Four-tOPV schedule | 6.20 | 0.41 | 43.70 | SCDC; WHO study [39] |
Two-IPV-two-bOPV schedule | 0.70 | 0.00 | 1.56 | SCDC; WHO position paper [1]; Sutter et al. [40]; Ivanova et al. [41] |
Four-IPV schedule | 0 | 0 | 0 | |
DALY caused by VAPP | 14 | 13 | 14 | Duintjer et al. [12], and Thompson et al. [14] |
bOPV, bivalent live attenuated oral polio vaccine; tOPV, trivalent live attenuated oral polio vaccine; CNY, Chinese Yuan; DALY, disability-adjusted life year; ICER, incremental cost-effectiveness ratio; IPV, inactivated polio vaccine; SCDC, Shanghai Municipal Center for Disease Control and Prevention; VAPP, vaccine-associated paralytic poliomyelitis.