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Effects of mec1-21 and rap1-17 on silencing at HML. Four isogenic strains were constructed in which the TRP1 gene was inserted at HML: LPY253 (MEC1 RAP1 [29]), RCY112-5c and RCY112-13b (both strains are mec1-21 RAP1), and RCY124-2a (MEC1 rap1-17). These strains were then plated onto medium lacking tryptophan. The rap1-17 mutation, but not the mec1-21 mutation, resulted in a silencing defect.
