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Distribution of the simulated and measured C(30 min’) values. (a) Simulated at population level; (b) simulated at individual level. (c) Measured concentrations within 1 h after infusion stops (available from 83 patients). Vertical broken line shows the recommended maximal C(30 min’) for long-duration treatment (12 mg/L). N, numbers of patients with C(30 min’) below 12 mg/L (left to the broken line), and above 12 mg/L (right to the broken line).
