Figure 7.

Simulations with the final model over 3 dosing intervals of 24 h each with 30 min infusion time. Once daily dose was (a–c) 3 mg/kg; (d–f) 4 mg/kg; (g–i) 5 mg/kg; (j–l) 7.5 mg/kg. (a,d,g,j) Simulated plasma-concentration time curves. (b,e,h,k) Respective distributions of simulated C(30 min’) of the third infusion. (c,f,i,l) Distributions of the simulated C(24 h’) of the third infusion. For further details, see Figure 6.