Table 3.

Fit parameters with SE and p of the final model. Values in parentheses are results when setting concentrations below the LOQ to LOQ/2 (0.15 mg/L).

Parameter	Reference Value for Intercept	Fit Value	SE	p
Structural model
ln(CL) = θ1 + θ5 × (ln(weight) − ln(4 kg)) + θ6 × (ln(creatinine) − ln(27 µM)) + θ7 × (ln(urea) − ln(3 mM)); CL = exp(θ1) × (weight/4 kg)θ5 × (creatinine/27 µM)θ6 × (urea/3 mM)θ7
θ1, Intercept (ln(CL, l × d−1))		2.267 (2.232)	0.0375 (0.0325)	-
θ5, Δ ln(body weight, kg)	ln(4 kg)	1.219 (1.171)	0.0761 (0.0654)	<0.0001
θ6, Δ ln(serum creatinine, µM)	ln(27 µM)	−0.964 (−0.916)	0.203 (0.180)	<0.0001
θ7, Δ ln(serum urea, mM)	ln(3 mM)	−0.168 (−0.147)	0.0826 (0.0733)	0.019
ln(V2′) = θ2 + θ8 × (ln(weight) − ln(4 kg)); V2’ = exp(θ2) × (weight/4 kg)θ8
θ2, Intercept (ln(V2’, l))		−0.174 (0.0937)	0.139 (0.0814)	-
θ8, Δ ln(body weight, kg)	ln(4 kg)	0.974 (1.314)	0.299 (0.111)	<0.001
ln(λ1) = θ3 ; λ1 = exp(θ3)
θ3, Intercept (ln(λ1, d−1))		3.644 (3.541)	0.201 (0.128)	-
ln(V1′) = θ4 + θ9 × (ln(weight) − ln(4 kg)); V1 = exp(θ4) × (weight/4 kg)θ9
θ4, Intercept (ln(V1, l))		0.204 (0.205)	0.0779 (0.0572)	-
θ9, Δ ln(body weight, kg)	ln(4 kg)	0.688 (0.625)	0.0864 (0.0670)	<0.0001
Variance of the random effects (inter-individual variance)
ln(CL)		0.107 (0.0830)	0.0972 (0.0125)
ln(V2′)		0.291 (0.186)	0.0972 (0.0410)
ln(V1)		0.0391 (0.0284)	0.0101 (0.0100)
Residual error
Residual error		0.102 (0.141)	0.0035 (0.0051)