Table 4.
Ranges of PK parameters for the final model and for the studied patient population. Population level (individual level).
| Parameter | Minimal Value | Mean Value | Median Value | Maximal Value |
|---|---|---|---|---|
| CL (mL/min) | 2.76 (1.47) | 9.39 (9.84) | 6.88 (6.84) | 73.2 (71.0) |
| CL (mL/min per 70 kg) | 42.4 (19.7) | 114 (121) | 117 (118) | 177 (298) |
| CL (mL/min per 1.73 m2) | 21.8 (8.7) | 49.4 (52.3) | 48.4 (48.0) | 113 (138) |
| Vz (l) (V1 + V2′) | 1.42 (0.915) | 2.58 (2.71) | 2.16 (2.24) | 12.4 (16.0) |
| Vz (l per 70 kg) | 24.8 (14.9) | 35.3 (37.1) | 35.8 (36.5) | 39.7 (104) |
| t1/2 (h) (ln(2) × Vz/CLz) | 1.72 (1.22) | 3.79 (4.06) | 3.53 (3.51) | 8.38 (16.9) |
| λ1 (h−1) | 1.59 (1.59) | |||
| t1/2 of distribution phase (h) (ln(2)/λ1) | 0.435 (0.435) | |||
| V1 (L) | 0.887 (0.762) | 1.45 (1.46) | 1.27 (1.27) | 5.46 (7.06) |
| V1 (L per 70 kg) | 10.9 (9.50) | 20.6 (20.6) | 21.1 (20.5) | 24.8 (33.4) |