Table 5.
Cytotoxic activity of derivatives 9–12 in human tumor cell lines (leukemia and breast) and in primate non-tumor kidney Vero cells a.
| Leukemia | Breast | Vero | |||||
|---|---|---|---|---|---|---|---|
| Compounds | HL60 | HEL | K562 | BT549 | MCF7 | SKBR3 | |
| 4g | 1.75 ± 0.21 | 1.00 ± 0.42 | 2.55 ± 0.78 | 3.55 ± 0.64 | >10 | >10 | >25 |
| 9 | 3.99 ± 0.12 | >10 | >10 | 8.85 ± 0.4 | 9.10 ± 0.57 | >10 | >25 |
| 10 | 2.15 ± 0.36 | 2.13 ± 0.81 | 2.30 ± 0.28 | 9.60 ± 0.42 | >10 | 1.50 ± 1.27 | 12.32 ± 0.11 |
| 11 | 2.70 ± 1.70 | 1.70 ± 0.14 | 4.87 ± 0.01 | 7.80 ± 1.13 | >10 | 3.25 ± 0.07 | 8.42 ± 1.34 |
| 12 | >10 | >10 | >10 | >10 | >10 | >10 | n.d. |
a Expressed as IC50 values given in μM and determined as means ± SD (n = 3).