Table 4.
DEMETER2 and CERES score comparison between MM cell lines and other cancer cell lines. DEMETER2 and CERES scores were calculated from CRISPR-Cas9 and RNAi-based viability assays, respectively.
| Gene | Dataset | T.Statistic | p-Value |
|---|---|---|---|
| ATP8B1 | RNAi (Broad) | −4.4246306 | 1.18 × 10−5 |
| FGFR4 | Combined RNAi (Broad, Novartis, Marcotte) | −4.6107503 | 4.74 × 10−6 |
| FOXD4 | Combined RNAi (Broad, Novartis, Marcotte) | −4.8020113 | 1.91 × 10−6 |
| ISG20 | CRISPR (Avana) Public 20Q1 | −3.949974 | 8.56 × 10−5 |
| MX1 | Combined RNAi (Broad, Novartis, Marcotte) | −7.990899 | 5.30 × 10−15 |
| NDC1 | CRISPR (Avana) Public 20Q1 | −5.029908 | 6.15 × 10−7 |
| NPTXR | Combined RNAi (Broad, Novartis, Marcotte) | −5.638059 | 2.47 × 10−8 |
| SF3B3 | CRISPR (Avana) Public 20Q1 | −4.0305542 | 6.13 × 10−5 |
| TMEM171 | RNAi (Novartis) | −3.6151729 | 3.39 × 10−3 |
| TNFRSF10B | RNAi (Novartis) | −3.996171 | 7.67 × 10−5 |
| UMPS | CRISPR (Avana) Public 20Q1 | −4.6553134 | 3.83 × 10−6 |