. 2021 Sep 24;14(10):965. doi: 10.3390/ph14100965

Table 2.

List of schedule 1 synthetic cannabinoids with their structures and adverse effects.

Name	Receptors	Adverse Effects
CP47,497 (5-(1,1-dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-phenol)	CB1 and CB2 agonist [149]	Increased heart rate, high/low blood pressure, coughing, and, vomiting [150]
JWH-018 (1-pentyl-3-(1-naphthoyl)indole)	CB1 and CB2 agonist [149]	Psychosis [151], hallucinations, vertigo, paresthesias, shaking, shivering, hypertension, dry mouth, vomiting, mydriasis, hypokalemia, extrasystoles, tachycardia, conjunctival hyperemia [134], and ischemic stroke [135]
JWH-073 (1-butyl-3-(1-naphthoyl)indole)	CB1 and CB2 agonist [149,152]	Altered mood and perception, red or bloodshot eyes, nausea, vomiting, listlessness, fever, sweating, and dryness of the mouth [150]
JWH-019 (1-hexyl-3-(1-naphthoyl)indole)	CB1 and CB2 agonist [152]	Confused speech, unstable appearance [150]
JWH-250 (1-pentyl-3-(2-methoxyphenylacetyl)indole)	CB1 and CB2 agonist [149]	Dilated unresponsive pupils and bloodshot eyes [153]
JWH-081 (1-pentyl-3-[1-(4-methoxynaphthoyl)]indole)	CB1 and CB2 agonist [152]	Slurred speech [153]
JWH-122 (1-pentyl-3-(4-methyl-1-naphthoyl)indole)	Agonist at CB1 and CB2 [154]	Hallucinations, disorientation, sedation, anxiety, agitation, tachycardia, hypertension, dyspnea, nausea, vomiting, hyperglycemia, and hypokalemia [155]
AM2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole)	Agonist at CB1 and CB2 [156]	Convulsions [157], Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension [158]
AM694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole)	Agonist at CB1 [159]	Agitation, hallucination, anxiety, and paranoia [159]
JWH-203 (1-pentyl-3-(2-chlorophenylacetyl)indole)	Agonist at CB1 and CB2 [156]	Head twitching, slurred speech, hallucination, dilated unresponsive pupils and bloodshot eyes [153]