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. 2021 Oct 14;11(10):1082. doi: 10.3390/life11101082

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the structure and domains of human G9a (a) and GLP (b). G9a and GLP contain different domains: an activation domain (AD), a Cys-rich region (Cys), an ankyrin repeat domain (ANK), and a SET domain composed of a core SET domain associated with pre- and a post-SET domains. G9a and GLP contain a nuclear localization signal (NLS). G9a also contains a Glu-rich region (E) and GLP a Glu/Asp-rich region (E/D). (c) Sequence alignment of G9a (NP_006700.3) and GLP (NP_079033.4). The alignment was performed using the MultAlin program [26] (http://multalin.toulouse.inra.fr/multalin) (accessed on 7 October 2021). Amino acids with 100% and >60% conservation are shown in red and blue, respectively.