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. 2021 Oct 14;22(20):11106. doi: 10.3390/ijms222011106

Figure 6.

Figure 6

Changes in the presynaptic localisation of GIRK2 in the hippocampus of P301S and APP/PS1 mice. Electron micrographs illustrating presynaptic immunoparticles for GIRK2 in the stratum radiatum of the CA1 region in 10 months old in wild type and P301S mice at and 12 months old in wild type and APP/PS1 mice, as detected using a pre-embedding immunogold technique. (A–F) In wild type mice (panels A,D), immunoparticles for GIRK2 were found at presynaptic sites, where they localised at the extrasynaptic plasma membrane (arrows) of axon terminals (at) establishing asymmetrical synapses with spines (s), and at intracellular sites (crossed arrows). Both in P301S and APP/PS1 mice (panels B,E), immunoparticles for GIRK2 found at presynaptic sites in axon terminals were more frequently detected at intracellular sites. Arrows and crossed arrows indicate to GIRK2 immunoparticles in dendritic spines (s) and shafts (Den) at extrasynaptic and intracellular sites, respectively. Scale bars: (A,B,D,E): 500 nm.