Table 1.
Aldose reductase (AR) enzyme kinetics. The values for glucose, galactose, and various cytotoxic compounds specific to the AR are shown.
| Cytotoxic Compound | Km (mM) | kcat (min−1) | kcat/Km (min−1·µM−1) |
Reference(s) |
|---|---|---|---|---|
| Acrolein (Figure 4a) | 0.80 ± 0.21 | 37.6 | 47 M−1 min−1 | [14] |
| 4HNE (Figure 4b) |
22 | 102 | 4.6 × 106 M−1 min−1 | [15] |
| Glyoxal (Figure 4c) |
514 | 154 | 3.0 × 105 M−1 min−1 | [15] |
| Methylglyoxal (Figure 4d) |
0.008 | 142 | 1.8 × 107 M−1 min−1 | [15,16] |
| ONE (Figure 4e) |
0.0042 ± 0.0046 | 92.2 ± 3.55 | 2190 ± 120 M−1 min−1 | [17] |
| Glucose (Figure 4f) |
0.68 | 0.15 | 9.1 × 102 M−1 min−1 | [16,18,19] |
| Galactose (Figure 4g) |
21 | 222 | 10.57 M−1 min−1 | [20] |