Table 3.
Changes in clinical characteristics and laboratory indices in the control group from baseline to month 6.
| Baseline | Month 6 | Mean difference | P value | |
|---|---|---|---|---|
| Body weight (kg) | 72.74 ± 14.24 | 72.51 ± 15.20 | −0.23 ± 4.70 | 0.654 |
| Body mass index (kg/m2) | 27.72 ± 4.61 | 27.63 ± 4.92 | −0.09 ± 1.75 | 0.619 |
| Mean arterial blood pressure | 115.98 ± 17.41 | 116.32 ± 19.12 | 0.34 ± 17.33 | 0.856 |
| Hemoglobin (g/dL) | 12.35 ± 1.94 | 12.1 ± 1.98 | −0.25 ± 0.88 | 0.012 |
| Estimated GFR (mL/min/1.73 m2) | 44.27 ± 21.25 | 42.36 ± 22.36 | −1.90 ± 10.91 | 0.116 |
| BUN (mg/dL) | 27.48 ± 13.33 | 30.28 ± 15.44 | 2.79 ± 8.30 | 0.004 |
| Serum creatinine (mg/dL) | 1.75 ± 0.69 | 1.88 ± 0.95 | 0.14 ± 0.42 | 0.004 |
| Fasting plasma glucose (mg/dL) | 167.19 ± 51.07 | 154.52 ± 58.65 | −12.67 ± 62.46 | 0.065 |
| Hemoglobin A1C (%) | 8.12 ± 1.70 | 7.98 ± 1.88 | −0.15 ± 1.70 | 0.451 |
| Serum potassium (mEq/L) | 4.59 ± 0.75 | 4.47 ± 0.50 | −0.12 ± 0.77 | 0.183 |
| Serum magnesium (mg/dL) | 1.98 ± 0.27 | 1.92 ± 0.24 | −0.05 ± 0.26 | 0.128 |
| Serum calcium (mg/dL) | 9.27 ± 0.51 | 9.25 ± 0.46 | −0.02 ± 0.52 | 0.729 |
| Serum phosphate (mg/dL) | 4.05 ± 0.85 | 3.95 ± 0.86 | −0.10 ± 0.88 | 0.316 |
| Serum albumin (g/dL) | 3.78 ± 0.46 | 3.74 ± 0.50 | −0.04 ± 0.28 | 0.239 |
| Urine protein, 24 hours (g/day) | 0.89 ± 1.60 | 1.39 ± 2.62 | 0.49 ± 2.22 | 0.060 |
| Coronary artery calcium score | 729.95 ± 1123.98 | 744.67 ± 1148.90 | 14.73 ± 161.66 | 0.395 |
| CAVI | 9.26 ± 1.44 | 8.69 ± 2.06 | −0.57 ± 1.81 | 0.005 |
| Serum myeloperoxidase (μg/L) | 653.06 ± 208.78 | 655.67 ± 232.65 | 2.61 ± 295.2 | 0.934 |
| Serum osteopontin (ng/mL) | 2442.31 ± 1368.92 | 2668.69 ± 1656.47 | 226.39 ± 2057.35 | 0.305 |
| Serum bone alkaline phosphatase (μg/L) | 15.59 ± 11.06 | 15.68 ± 8.24 | 0.08 ± 11.45 | 0.947 |
| Urine NGAL (ng/mg creatinine) | 333.67 ± 627.23 | 590.95 ± 1252.05 | 257.28 ± 1047.29 | 0.024 |
| Urine Kim (ng/mg creatinine) | 1.11 ± 1.07 | 0.61 ± 0.74 | −0.50 ± 0.90 | <0.001 |
| Urine LFABP (μg/mg creatinine) | 48.86 ± 67.14 | 55.47 ± 86.31 | 6.6 ± 88.94 | 0.488 |
Data are presented as the mean ± SD. CAVI: cardio-ankle vascular index; LFABP: liver acid-binding protein; NGAL: neutrophil gelatinase-associated lipocalin; Kim-1: kidney injury molecule-1.