Table 4.
Comparison of mean changes in various parameters from baseline to month 6 between the two groups.
| Mean change | Gemigliptin (N = 94) | Control (N = 88) | 95% CI | P value |
|---|---|---|---|---|
| Body weight (kg) | 0.22 ± 4.20 | −0.23 ± 4.70 | -0.87, 1.75 | 0.506 |
| Body mass index (kg/m2) | 0.07 ± 1.57 | −0.09 ± 1.75 | -0.33, 0.65 | 0.512 |
| Mean arterial blood pressure | −3.31 ± 18.02 | 0.34 ± 17.33 | -8.89, 1.59 | 0.171 |
| Hemoglobin (g/dL) | −0.26 ± 0.99 | −0.25 ± 0.88 | -0.30, 0.28 | 0.952 |
| Estimated GFR (mL/min/1.73 m2) | −1.03 ± 10.00 | −1.90 ± 10.91 | -2.29, 4.04 | 0.587 |
| BUN (mg/dL) | 1.27 ± 8.75 | 2.79 ± 8.30 | -4.16, 1.10 | 0.254 |
| Serum creatinine (mg/dL) | 0.09 ± 0.33 | 0.14 ± 0.42 | -0.16, 0.06 | 0.389 |
| Fasting plasma glucose (mg/dL) | −33.34 ± 59.40 | −12.67 ± 62.46 | -38.96, -2.38 | 0.027 |
| Hemoglobin A1C (%) | −0.67 ± 1.59 | −0.15 ± 1.70 | -1.05, -0.01 | 0.048 |
| Serum potassium (mEq/L) | −0.08 ± 0.49 | 0.44 ± 4.02 | -0.96, 1.44 | 0.734 |
| Serum magnesium (mg/dL) | 0.22 ± 1.19 | −0.05 ± 0.26 | -0.01, 0.56 | 0.057 |
| Serum calcium (mg/dL) | −0.26 ± 1.03 | −0.02 ± 0.52 | -0.50, 0.02 | 0.073 |
| Serum phosphate (mg/dL) | −0.14 ± 0.69 | −0.10 ± 0.88 | -0.29, 0.23 | 0.800 |
| Serum albumin (g/dL) | 0.04 ± 0.35 | −0.04 ± 0.28 | -0.03, 0.18 | 0.152 |
| Urine protein, 24 hours (g/day) | −0.01 ± 2.96 | 0.49 ± 2.22 | -1.35, 0.35 | 0.246 |
| Coronary artery calcium score | 35.21 ± 252.88 | 14.73 ± 161.66 | -42.07, 83.03 | 0.519 |
| CAVI | −0.28 ± 1.58 | −0.57 ± 1.81 | -0.22, 0.79 | 0.265 |
| Serum myeloperoxidase (μg/L) | −20.82 ± 298.75 | 226.39 ± 2057.35 | -543.35, 711.91 | 0.596 |
| Serum osteopontin (ng/mL) | 310.67 ± 2,222.67 | 226.39 ± 2057.35 | -543.35, 711.91 | 0.791 |
| Serum bone alkaline phosphate (μg/L) | −5.84 ± 10.65 | 0.08 ± 11.45 | -9.16, -2.69 | <0.001 |
| Urine NGAL (ng/mg creatinine) | −71.53 ± 837.30 | 257.28 ± 1,047.29 | -606.19, -51.43 | 0.020 |
| Urine Kim (ng/mg creatinine) | −0.28 ± 1.15 | −0.50 ± 0.90 | -0.08, 0.52 | 0.156 |
| Urine LFABP (μg/mg creatinine) | −54.17 ± 141.64 | 6.6 ± 88.94 | -95.30, -26.24 | 0.001 |
Data are presented as the mean ± SD and 95% CI. CAVI: cardio-ankle vascular index; LFABP: liver acid-binding protein; NGAL: neutrophil gelatinase-associated lipocalin; Kim-1: kidney injury molecule-1.