Table 2.
Difference analysis for the potential predictors of ovarian response in IVF-ET.
| Variables, n (%) | Total (n = 336) | HR group (n = 167) | NR group (n = 169) | Statistic | P | |
|---|---|---|---|---|---|---|
| Baseline | Age, years, mean ± SD | 31.26 ± 3.79 | 30.73 ± 3.67 | 31.79 ± 3.85 | t = −2.588 | 0.010 |
| Smoking history | — | 0.686 | ||||
| Active smoking | 5 (1.49) | 3 (1.80) | 2 (1.18) | |||
| Passive smoking | 48 (14.29) | 26 (15.57) | 22 (13.02) | |||
| No | 283 (84.23) | 138 (82.63) | 145 (85.80) | |||
| Type of infertility | χ 2 = 3.530 | 0.060 | ||||
| Primary | 130 (38.69) | 73 (43.71) | 57 (33.73) | |||
| Secondary | 206 (61.31) | 94 (56.29) | 112 (66.27) | |||
| Pregnancy history | χ 2 = 1.452 | 0.228 | ||||
| No | 132 (39.29) | 71 (42.51) | 61 (36.09) | |||
| Yes | 204 (60.71) | 96 (57.49) | 108 (63.91) | |||
| BMI, kg/m2, mean ± SD | 21.99 ± 2.97 | 22.05 ± 3.06 | 21.94 ± 2.88 | t = 0.340 | 0.734 | |
| Age at menarche, years, mean ± SD | 13.14 ± 1.20 | 13.06 ± 1.11 | 13.22 ± 1.29 | t = −1.259 | 0.209 | |
| Mean menstrual cycle, days, mean ± SD | 29.28 ± 2.04 | 29.62 ± 2.15 | 28.94 ± 1.87 | t = 3.091 | 0.002 | |
| Duration of infertility, years, M (Q1, Q3) | 3.00 (2.00, 4.00) | 3.00 (2.00, 5.00) | 3.00 (1.00, 4.00) | Z = 1.430 | 0.153 | |
| AFC, M (Q1, Q3) | 15.00 (12.00, 19.00) | 19.00 (16.00, 22.00) | 12.00 (10.00, 14.00) | Z = 13.879 | <0.001 | |
| MC3 | LH, mu/ml, M (Q1, Q3) | 4.79 (3.54, 6.02) | 4.87 (3.61, 6.01) | 4.71 (3.32, 6.04) | Z = 0.274 | 0.784 |
| E2, pmol/L, M (Q1, Q3) | 36.16 (26.26, 46.38) | 35.23 (23.22, 45.70) | 37.56 (27.80, 47.44) | Z = −1.903 | 0.057 | |
| P, nmol/L, M (Q1, Q3) | 0.40 (0.26, 0.59) | 0.46 (0.31, 0.66) | 0.32 (0.22, 0.48) | Z = 4.626 | <0.001 | |
| FSH, U/L, mean ± SD | 6.56 ± 1.69 | 6.34 ± 1.65 | 6.77 ± 1.71 | t = −2.304 | 0.022 | |
| AMH, ng/ml, M (Q1, Q3) | 3.68 (2.46, 5.25) | 5.20 (4.19, 6.17) | 2.69 (2.01, 3.34) | t = 14.188 | <0.001 | |
| Endometrial thickness, mm, mean ± SD | 10.09 ± 2.10 | 10.18 ± 2.07 | 10.00 ± 2.13 | t = 0.798 | 0.425 | |
| HCG day | Dosing days of Gn, days, mean ± SD | 12.13 ± 2.63 | 12.26 ± 2.55 | 12.01 ± 2.71 | t = 0.86 | 0.393 |
| Initial dose of Gn, IU, mean ± SD | 217.82 ± 54.94 | 208.80 ± 50.98 | 226.70 ± 57.37 | t = −3.02 | 0.003 | |
| Total dose of Gn, IU, mean ± SD | 2861.99 ± 919.51 | 2753.70 ± 821.50 | 2969.00 ± 998.00 | t = −2.16 | 0.032 | |
| Endometrial thickness, mm, mean ± SD | 11.10 ± 2.32 | 11.31 ± 2.34 | 10.89 ± 2.28 | t = 1.67 | 0.095 | |
| LH, mu/mL, M (Q1, Q3) | 0.95 (0.55, 1.87) | 0.84 (0.53, 1.42) | 1.15 (0.55, 2.14) | Z = −2.161 | 0.031 | |
| E2, pmol/L, M (Q1, Q3) | 2986.00 (2074.86, 4857.50) | 4403.00 (2811.00, 6000.00) | 2405.00 (1657.00, 3483.00) | Z = 8.737 | <0.001 | |
| P, nmol/L, M (Q1, Q3) | 0.95 (0.67, 1.32) | 1.16 (0.82, 1.56) | 0.81 (0.57, 1.12) | Z = 6.089 | <0.001 | |
HR group: high response group; NR group: normal response group; BMI: body mass index; AFC: antral follicle count; MC3: menstrual cycle day 3; LH: luteinizing hormone; E2: estradiol; P: progesterone; FSH: follicle-stimulating hormone; AMH: anti-Müllerian hormone; HCG: human chorionic gonadotropin; Gn: gonadotropin; Mean ± SD: mean ± standard deviation; M (Q1, Q3): median and quartile; χ2: measured the degree of correlation between two categorical variables; t: compared the difference between the two groups; Z: represented the rank sum test for the comparison of two samples.