. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: J Mol Med (Berl). 2021 Jul 28;99(11):1571–1583. doi: 10.1007/s00109-021-02118-7

Table 3.

Study variables for Coloradan children with otitis media by occurrence of middle ear fluid (MEF) at surgery^a

Variable^b	(+)MEF (n=61)^c	(−)MEF (n=30)^c	p-value^d
CDHR3 p.Cys529Tyr	14 (23.0)	15 (50.0)	0.035*
FUT2 p.Trp154*	42 (68.9)	22 (73.3)	1
PLG p.Asp472Asn	31 (50.8)	16 (53.3)	0.82
Age	3.4 (3.7)	3.3 (2.6)	0.86
Male	42 (68.9)	18 (60.0)	0.55
Not White non-Hispanic	16 (26.2)	7 (23.3)	0.97
Family history of OM	36 (59.0)	22 (73.3)	0.27
Breastfed	55 (90.2)	26 (86.7)	0.88
Attended daycare	47 (77.0)	18 (60.0)	0.15
Exposure to cigarette smoke	7 (11.5)	5 (16.7)	0.74
History of allergies	13 (21.3)	11 (36.7)	0.21
History of asthma	4 (6.6)	3 (10.0)	0.87
History of allergic rhinitis	21 (34.4)	16 (53.3)	0.13
History of sinusitis	9 (14.8)	8 (26.7)	0.28
Antibiotic use	53 (86.9)	28 (93.3)	0.57
RAOM	38 (62.3)	28 (93.3)	0.004*

All tests were performed with chi-square analyses except for age, which was performed with student’s t-test.

All three variants tested are in Hardy-Weinberg equilibrium within the Coloradan cohort. Previous antibiotic use was also associated with the CDHR3 p.Cys529Tyr variant (p=0.03). RAOM, recurrent acute otitis media.

Numbers indicate counts (%), except for age which denotes average age in years (SD).

Statistically significant variables are in bold font.