Table 2.
Abundance association of oral bacterial taxa with lung cancer riska
| Taxon | Median relative abundance (%) |
OR (95% CI)b | P b | |
|---|---|---|---|---|
| Cases (n=156) | Controls (n=156) | |||
| Phylum Firmicute | ||||
| Family Lachnospiraceae_[XIV] | 0.205 | 0.226 | 0.76 (0.59–0.98) | 0.037 |
| Family Peptoniphilaceae | 0.012 | 0.030 | 0.82 (0.69–0.97) | 0.023 |
| Genus Parvimonas | 0.012 | 0.028 | 0.83 (0.70–0.98) | 0.030 |
| Species P. micra | 0.012 | 0.028 | 0.83 (0.71–0.98) | 0.031 |
| Family Peptostreptococcaceae_[XI] | 0.067 | 0.108 | 0.80 (0.66–0.97) | 0.022 |
| Family Erysipelotrichaceae | 0.014 | 0.018 | 0.81 (0.67–0.99) | 0.038 |
a
The taxa had median relative abundance >0.01% among control subjects.
b
Odds ratios (ORs), 95% confidence intervals (CIs), and P values were calculated from conditional logistic regression on normalized taxa counts using centered log-ratio transformation, adjusted for unmatched covariates including smoking pack-years, alcohol drinking status, total energy intake, BMI, last time of dentistry visit, and sequencing batch.