Table 3.
Prevalence association of oral bacterial taxa with lung cancer riska
| N (%) carriage |
||||
|---|---|---|---|---|
| Taxon | Cases (n=156) | Controls (n=156) | OR (95% CI)b | P b |
| Phylum Bacteroidetes | ||||
| Genus Bacteroidetes_[G-5] | 39 (25.0) | 55 (35.3) | 0.55 (0.30–1.00) | 0.044 |
| Species Alloprevotella sp._oral_taxon_912 | 41 (26.3) | 56 (35.9) | 0.36 (0.17–0.73) | 0.017 |
| Species Capnocytophaga sputigena | 66 (42.3) | 89 (57.1) | 0.53 (0.31–0.92) | 0.021 |
| Phylum Firmicute | ||||
| Genus Lactococcus | 23 (14.7) | 39 (25.0) | 0.43 (0.21–0.88) | 0.017 |
| Species L. lactis | 23 (14.7) | 39 (25.0) | 0.43 (0.21–0.88) | 0.017 |
| Genus Peptoniphilaceae_[G-1] | 17 (10.9) | 34 (21.8) | 0.43 (0.21–0.88) | 0.028 |
| Species P_[G-1]. sp._oral_taxon_113 | 17 (10.9) | 34 (21.8) | 0.43 (0.19–0.94) | 0.028 |
| Phylum Fusobacteria | ||||
| Species Leptotrichia sp._oral_taxon_225 | 67 (42.9) | 88 (56.4) | 0.57 (0.34–0.99) | 0.041 |
| Phylum Synergistetes | ||||
| Species Fretibacterium fastidiosum | 46 (29.5) | 66 (42.3) | 0.54 (0.31–0.94) | 0.026 |
a
The taxa had median relative abundance ≤0.01% and carriage >20% among control subjects.
b
Odds ratios (ORs), 95% confidence intervals (CIs), and P values were calculated from conditional logistic regression with non-carriers as the reference, adjusted for unmatched covariates including smoking pack-years, alcohol drinking status, total energy intake, BMI, last time of dentistry visit, sequencing batch, and sequencing depth.