Figure 2. Regulation of apoptosis by MYC.

MYC can promote apoptosis through both intrinsic (mitochondrial) and extrinsic (death receptor-mediated) mechanisms by regulating many key components of these pathways. Common anti-cancer drugs (e.g., chemotherapeutics) often trigger both apoptotic pathways, thereby increasing their reliance on MYC. Additionally, the extrinsic pathway can be specifically engaged by death receptor agonists or DR4-activating antibodies (e.g., mapatumumab).