Table 1.

Patient disposition

	Dose, mg/kg	n	Reason for withdrawal
Dose escalation (n = 26)	Not dosed	1	Other (patient enrolled but not included in the safety population)
	3.2	6	PD (n = 2), AE (n = 2), symptomatic deterioration (n = 2)
	6	3	PD (n = 2), death (n = 1)
	10	4	PD (n = 3), symptomatic deterioration (n = 1)
	15	3	PD (n = 2), withdrew consent (n = 1)
	20	5	PD (n = 2), withdrew consent (n = 1), symptomatic deterioration (n = 2)
	40/20	4	PD (n = 3), symptomatic deterioration (n = 1)
Dose expansion (n = 18)	40/20	18	PD (n = 14), investigator decision (n = 1), symptomatic deterioration (n = 3)

40/20 40 mg/kg loading dose followed by 20 mg/kg maintenance dose, AE adverse event, PD progressive disease