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Drug susceptibility phenotypes of molecularly cloned recombinant viruses
| Virus clone | Nelfinavir IC (fold resistance) ata:
|
|
|---|---|---|
| 50% | 90% | |
| WT | 76.7 | 146.0 |
| D30N | 339.7 (4.4) | 1148.0 (7.9) |
| D30N/L63P | 549.6 (7.2) | 1190.0 (8.1) |
IC, inhibitory concentration expressed in nanomolar concentration. The ICs were determined in PBMC cultures by using supernatant fluid p24 antigen as the end point. Fold resistance indicates the IC of HIV variants relative to the WT (NL4-3).
