Table 1.

Metabolic pathways and their associated metabolic features down regulated in the microbial cell after the exposure of the nanocomposite

ESI-Mode	Metabolites	Pathway(s) involved	Fold change	p-value	m/z	Retention time	Adduct
Positive	UTP	UDP-N-acetyl-D glucosamine biosynthesis I Anhydromuropeptides recycling	204.8	2.0e-3	506.9561	4.05	M + Na[1 +]
Negative	CDP-glycerol	Teichoic acid (poly-glycerol) biosynthesis	162.8	2.6e-4	460.0502	3.59	M-H2O + H[1 +]
Negative	dTTP	Pyrimidine deoxyribonucleotide phosphorylation	125.5	1.1e-3	504.9785	3.73	M + Na[1 +]
Positive	dGDP	Guanosinedeoxyribonucleotides de novo biosynthesis I	16.0	9.6e-4	410.0251	5.96	M-H2O + H[1 +
Negative	(2S,3S)-2,3-dihydroxy-2,3- dihydrobenzoate	2,3-dihydroxybenzoate biosynthesis	15.6	5.9e-7	140.0233	5.28	M-NH3 + H[1 +]
Positive	Succinate	4-aminobutanoate degradation II	9.7	3.9e-4	136.0610	5.41	M + NH3 + H[1
Positive	CMP	Teichoic acid (poly-glycerol) biosynthesis	7.6	1.1e-4	324.0582	5.46	M + H[1 +]
Negative	Indole	L-tryptophan biosynthesis	4.2	7.1e-4	135.0918	4.59	M + NH3 + H[1 +
Positive	Meso-diaminopimelate	UDP-N-acetylmuramoylpentapeptide biosynthesis I	3.9	1.9e-3	175.1069	5.29	M-H2O + H[1 +
Positive	Histidinal	L-histidine biosynthesis	3.2	7.7e-4	82.0391	2.01	M + H + Na[2 +]
Positive	Uracil	Pyrimidine deoxyribonucleosides degradation	2.0	1.4e-4	113.0343	1.68	M + H[1 +]
Positive	N-acetyl-L-glutamate 5- semialdehyde	L-arginine biosynthesis II (acetyl cycle) L-ornithine biosynthesis I	1.7	1.9e-3	191.1022	5.89	M + NH3 + H[1