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. 2021 Oct 23;12(11):993. doi: 10.1038/s41419-021-04297-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The expression levels of LSD1 were detected in different types of cancers from the GEPIA public database. B The GEPIA database revealed that LSD1 expression was significantly upregulated in HNSCC patients. C Correlation between the expression level of LSD1 and the pathological stage of HNSCC patients (GEPIA). D Representative images of LSD1 expression in normal tissues, leukoplakia tissues, and HNSCC tissues via immunohistochemical (IHC) staining. Scale bar: 100 μm. E IHC scores for LSD1 expression in normal, leukoplakia, and HNSCC tissues. F IHC scores for LSD1 expression in HNSCC samples in different TNM stages. G IHC scores for LSD1 expression in HNSCC with different grades. H High LSD1 expression significantly correlates with poor survival in HNSCC patients. The survival rates of patients with LSD1-low and LSD1-high tumors (P < 0.01) were determined using Kaplan–Meier survival test. (*p < 0.05, **p < 0.01).