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. 2021 Oct 23;12(11):992. doi: 10.1038/s41419-021-04283-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B High phosphate (Pi) triggered the combination of sEH and Sirt3. Cellular lysates were immunoprecipitated (IP) with anti-sEH antibody and then immunoblotted (IB) with anti-Sirt3 (A), or IP with anti-Sirt3 antibody and then IB with anti-sEH (B). C, D High Pi treatment markedly accelerated Sirt3 degradation in wild-type (WT) compared with Ephx2⁻^/− VSMCs. CHX indicates cycloheximide. Data are presented as mean ± SD. *P < 0.05 vs. WT 6 h. Data are presented as mean ± SD. *P < 0.05.