Table 2.

Single amino acid polymorphisms related to antimicrobial resistance in 14 colistin-resistant OXA-48-producing K. pneumoniae strains

Protein	Strains
	Cephalosporin resistance	Elfamycin resistance	Fosfomycin resistance	Repressor of multi-drug resistance operon	Fluoroquinolone resistance			Colistin resistance
	PBP3	EF-Tu	UhpT	MarR	ParC	GyrA	GyrB	PhoP	PhoQ	PmrA	PmrB	MgrB	RamA	AcrB	CrrB
P6	D350N, S357N	R234F	E350Q	S3N	S80I	S83I	E466D	Intact	D150G	Intact	R256G	Intact	D71B	Intact	Intact
P7	D350N, S357N	R234F	E350Q	S3N	S80I	S83I	E466D	Intact	D150G	Intact	R256G	Intact	D71B	Intact	A200E
P26	D350N, S357N	R234F	E350Q	S3N	S80I	S83I	E466D	Intact	D150G	Intact	R256G	Intact	D71B	Intact	Intact
P31	D350N, S357N	R234F	E350Q	Intact	S80I	S83I	Intact	Intact	D150G	Intact	R256G	Intact	Intact	Intact	Intact
P32	D350N, S357N	R234F	E350Q	E86K	S80I	S83I	Intact	Intact	D150G	Intact	R256G	Insertion of ISKpn72	Intact	Intact	Intact
P33	D350N, S357N	R234F	E350Q	E86K	S80I	S83I	Intact	Intact	D150G	Intact	R256G	C28W	Intact	Intact	Intact
P35	D350N, S357N	R234F	E350Q	Intact	S80I	S83F	Intact	Intact	Intact	A41T	Intact	Stop codon (Q30*)	Intact	Intact	Intact
P36	D350N, S357N	R234F	E350Q	E86K	S80I	S83I	Intact	Intact	D150G	Intact	R256G	Intact	Intact	Intact	Intact
P37	D350N, S357N	R234F	E350Q	E86K	S80I	D87N	Intact	Intact	D150G	A218V	Intact	Deletion	Intact	Intact	ND
P38	D350N, S357N	R234F	E350Q	Intact	P403A	S83F	Intact	Intact	Intact	A41T	Intact	Stop codon (Q30*)	Intact	Intact	Intact
P40	D350N, S357N	R234F	E350Q	E86K	S80I	S83I	Intact	Intact	D150G	Intact	R256G	Intact	Intact	Intact	Intact
P42	D350N, S357N	R234F	E350Q	E86K	S80I	S83I	Intact	Intact	D150G	Intact	R256G	C28W	Intact	Intact	Intact
P43	D350N, S357N	R234F	E350Q	E86K	S80I	D87G	E466D	Intact	D150G	Intact	R256G	Intact	I25T	Intact	Intact
P44	D350N, S357N	R234F	E350Q	E86K	S80I	S83I	Intact	Intact	D150G	Intact	R256G	Intact	intact	Intact	Intact

ND means not detected