Fig. 8.

Model for growth resumption after cell division. Rga4 localizes to cell sides during G2 (magenta). Entering mitosis, Rga4 extends all the way to the ends (magenta). Upon anaphase-promoting complex activation, the MOR pathway is inactivated and Cdc42 activation and growth (green) stop (Ray et al., 2010; Nunez et al., 2016). After mitosis, MOR is activated and Rga4 is lost from the ends, which now resume growth (Ray et al., 2010; Nunez et al., 2016). In PrESS cells, LatA treatment delays cytokinesis while mitosis proceeds. In these cells, Rga4 is removed from cell ends before cytokinesis completes, resulting in local Cdc42 activation and growth at the expense of cytokinetic events at the cell middle. Thus, we propose that growth resumption upon completion of cell division is independent of cytokinesis and dependent on cell-cycle cues.