Table 6. Relation of failure of biological therapy and allergic reaction to taken biological therapy, clinical and laboratory data, and drugs used.
* Mann-Whitney test
Anti-CCP; Anti-cyclic citrullinated peptide, Anti-MCV; Anti-mutated citrullinated vimentin, ESR; erythrocyte sedimentation rate, CRP; C-reactive protein, dsDNA; double-stranded DNA, ANA; antinuclear antibodies, DAS-28; disease activity score, NSAIDs; nonsteroidal anti-inflammatory drugs, HB level; hemoglobin level, MTX; methotrexate
| Variable | P-value | χ2 | P-value | ||
| Absent No. (%) | Present No. (%) | ||||
| Allergic reaction to taken biological therapy | Yes | 31 (100) | 0 (0.0) | 24.22 | < 0.001 |
| No | 165 (54.3) | 139 (45.7) | |||
| Anti-CCP | Yes | 96 (57.8) | 70 (42.2) | 0.06 | 0.803 |
| No | 100 (59.2) | 69 (40.8) | |||
| Anti-MCV | Yes | 11 (57.5) | 82 (42.5) | 1.67 | 0.433 |
| No | 85 (60.3) | 56 (39.7) | |||
| Not applicable | 0 (0.0) | 1 (100) | |||
| ESR | High | 97 (56.4) | 75 (43.6) | 0.65 | 0.42 |
| Normal | 99 (60.7) | 64 (39.3) | |||
| CRP | > 3 | 135 (57.2) | 101 (42.8) | 2.13 | 0.343 |
| ≤ 3 | 61 (82.2) | 37 (37.8) | |||
| Not applicable | 0 (0.0) | 1 (100) | |||
| dsDNA | 0-200 | 75 (45) | 64 (46) | 2.1 | 0.53 |
| 201-300 | 61 (60.4) | 40 (39.6) | |||
| 301-800 | 57 (63.3) | 33 (36.7) | |||
| > 800 | 3 (60) | 2 (40) | |||
| ANA | Positive | 114 (56.7) | 87 (43.3) | 0.66 | 0.415 |
| Negative | 82 (61.2) | 52 (88.8) | |||
| Activity | Yes | 164 (58.6) | 116 (41.4) | 0.003 | 0.957 |
| No | 32 (58.2) | 23 (41.8) | |||
| DAS-28 | ≤ 2.6 | 2 (100) | 0 (0.0) | 5.35 | 0.148 |
| 2.6-3.2 | 70 (61.4) | 441 (38.6) | |||
| 3.2-5.1 | 98 (60.1) | 65 (39.9) | |||
| ≥ 5.1 | 26 (46.4) | 30 (53.6) | |||
| NSAIDs | Yes | 169 (62.6) | 101 (37.4) | 9.56 | 0.002 |
| No | 27 (41.5) | 38 (58.5) | |||
| Steroid dose | < 5mg | 129 (67.9) | 61 (32.1) | 20.88 | < 0.001 |
| 5-10mg | 64 (48.1) | 69 (51.9) | |||
| > 10mg | 2 (18.2) | 9 (81.8) | |||
| Not applicable | 1 (100) | 0 (0.0) | |||
| Quantitative variables | Duration | 47.55± 85.27 | 26.55± 36.48 | 3.74* | < 0.001 |
| HB level | 11.73 ± 1.72 | 11.85± 1.75 | 0.85* | 0.393 | |
| Platelet level | 330.59±114.47 | 315.29 ±76.7 | 0.87* | 0.38 | |
| Creatine level | 96.93± 50.8 | 76.98± 75.93 | 1.04* | 0.298 | |
| MTX Dose | 8.58 ± 4.58 | 8.82 ± 4.18 | 0.81* | 0.215 | |