Table 3:
Grade 3 to 5 Adverse Events Possibly, Probably, or Definitely Associated with Study Treatment
| Toxicity Type | Subprotocol | ||
|---|---|---|---|
| EAY131-Z1A (n=50) | |||
| Grade | |||
| 3 | 4 | 5 | |
| (n) | (n) | (n) | |
| Heart failure | 1 | - | - |
| Myocardial infarction | 1 | - | - |
| Eye disorders | 1 | - | - |
| Mucositis oral | 1 | - | - |
| Nausea | 1 | - | - |
| Small intestinal obstruction | 1 | - | - |
| Fatigue | 1 | - | - |
| Multi-organ failure | - | - | 1 |
| Edema limbs | 1 | - | - |
| Urinary tract infection | 1 | - | - |
| Alanine aminotransferase increased | 1 | - | - |
| Alkaline phosphatase increased | 1 | - | - |
| Aspartate aminotransferase increased | 1 | - | - |
| CPK increased | 2 | - | - |
| Lymphocyte count decreased | 2 | - | - |
| White blood cell decreased | 1 | - | - |
| Ejection fraction decreased | 1 | - | - |
| Anorexia | 1 | - | - |
| Dehydration | 1 | - | - |
| Hypoalbuminemia | 1 | - | - |
| Hyponatremia | 1 | - | - |
| Hypophosphatemia | 1 | - | - |
| Muscle weakness lower limb | 1 | - | - |
| Muscle weakness upper limb | 1 | - | - |
| Syncope | 1 | - | - |
| Rash acneiform | 3 | - | - |
| Skin and subcutaneous tissue disorders | 1 | - | - |
| Hypertension | 6 | - | - |