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Conservation of SARS-CoV-2 S subunits. Sequence conservation visualised on the closed structure of SARS-CoV-2 spike (PDB ID 6ZGE) [119]. Chain A was coloured according conservation calculated with the ConSurf algorithm (https://consurf.tau.ac.il) from the sequences of 24 animal and human coronaviruses. The other two chains are depicted in ling and dark grey respectively.
